After wins over Chris Avalos, Alejandro Gonzalez Jr and Scott Quigg, the last of which took place in front of a sell-out Manchester crowd, Frampton would move up a weight.
Competing at super featherweight, the Jackal faced Leo Santa Cruz in New York City, in a fight that has gone down history.
In a brilliant back and forth encounter, the Northern Irishman became a two-weight world champions after winning a majority of decision.
However, he would lose a rematch via the same method and would never win another title.
In December 2018, Frampton was involved in his final domestic dust-up, when he and Josh Warrington were involved in yet another fight of the year contender.
The Englishman would came out on top, winning by a unanimous points decision. Frampton hinted he could retire after that bout, but will do so now, with a record of 28 wins from 31 fights and three defeats.