The White City Retail Park on Chester Road in Old Trafford has been partially sealed off following reports of an explosion.
Emergency services are believed to be at the scene following the incident.
Chester Road, heading southbound out of the city, is understood to be closed.
Cadent Gas have confirmed they have engineers on the scene, but they do not believe the incident is related to the gas network.
The cause of the explosion has yet to be confirmed.
A number of popular retail outlets are situated inside the shopping park including Aldi, Currys, M&S, Nando’s, The Gym and Furniture Village.
A spokesperson for Cadent Gas told the Manchester Evening News: “We have arrived on scene and are checking our assets but there is no suggestion that this is connected to the gas network.”