The Duke and Duchess of Cambridge will lead the Mental Health Minute on Friday.
The special message is broadcast each year across 500 radio stations in the UK.
It is the fifth year William and Kate have been involved in the initiative.
But for the first time the couple will be the sole speakers rather than being joined by celebrities.
Mental Health Awareness Week kicks off today, with this year’s theme loneliness.
The Mental Health Minute initiative was created by Radiocentre and is delivered in partnership with William and Kate’s Royal Foundation.
The 2022 Minute is in support of Better Health – Every Mind Matters, which offers advice to tackle loneliness and provides tips to help people look after their mental wellbeing.
Later this week, William and Kate will visit Scotland where they will carry out a number of engagements focusing on mental health.
The Cambridges will meet students at the University of Glasgow to talk about their mental health and wellbeing during the Covid pandemic, including those whose studies include mental health research and members of the university’s Society for Mental Health.
The Duke will also visit the Heart of Midlothian Football Club in Edinburgh to hear about a programme called the ‘Changing Room’ which uses football to help men aged 30-64 talk about their mental health.
MORE TO FOLLOW