At least one southbound lane was shut near Castle Donington and traffic on both the M1 and the A50 are being affected by the accident.
The lanes have since been reopened and the crash moved to the hard shoulder.
However, traffic is still moving extremely slowly all the way to Long Eaton.
Traffic cameras show queues of traffic on the approach to the scene of the crash.
It comes after a serious collision yesterday morning closed the northbound M1 between Leicester and Loughborough for the majority of the day.
UPDATES TO FOLLOW…