According to National Highways, the M4 in Berkshire is currently blocked eastbound between Junction 11 and Junction 10.
The blockage is due to a collision.
Traffic officers from Thames Valley Police are on the scene with other emergency services.
The agency also Tweeted: “2 lanes remain closed whilst the emergency services work at the scene.
“Please take care on approach, thank you for your patience.”
Emergency services are currently working on the scene where two cars and a lorry have been involved.
Inrix data company have reported traffic has been queuing for four miles due to the accident between junction 11 and Junction 10.
The eastbound section of the M4 is expected to clear between 4 pm and 4.15 pm and normal traffic conditions are expected between 4.30 and 4.45 pm.
There are current delays of 10 minutes and expected traffic.
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Inrix, the traffic data company, said: “Two lanes closed and queueing traffic for two miles due to an accident on M4 Eastbound between J11 A33 Basingstoke Road (Reading) and J10 A329(M) Wokingham / Bracknell. Cameras show lanes three and four (of four) are closed.
Traffic was initially held very briefly at 12:40 pm.”