The Department for Environment, Food and Rural Affairs (DEFRA) declared the zone around Preston, South Ribble, Wyre and Fylde.
This came after the Avian Influenza virus was confirmed at a farm in Salwick on the fringe of Preston.
DEFRA said that all birds on the infected farm will be culled.
It is also implementing a temporary disease control zone that covers massive parts of the Wyre, Fylde, Preston and South Ribble areas.
The disease control zone came into force at 8.30pm last night and extends around six miles in every direction from the farm, LancsLive reported.
The wider ‘Zone B’ reaches Bamber Bridge, Lytham, Catterall and Much Hoole.
There is also a smaller 1.8-mile radius ‘Zone A’, around the farm, includes Swillbrook, Woodplumpton, Lea Town, Salwick, and Treales.
Cases of the Avian Influenza were confirmed on Friday after vets were called to the farm.
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